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PI = Principal Investigator CDA= Confidential Disclosure... VMRF and Sponsor negotiate terms VMRF receives 1 fully  executed copy for file,  one for... Sponsor signs and sends fully executed CDA to VMRF PI signs CDA, then sends CDA to VMRF VMRF sends CDA to Sponsor ACOS R&D signs CDA VMRF sends CDA to  PI for signature, if required VMRF reviews; Is CDA ready for ACOS R&D signature? PI forwards proposed/draft CDA  to VMRF Sponsor sends CDA template to PI Finish Start